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Mouse model of colorectal and intestinal cancer : ウィキペディア英語版
Mouse model of colorectal and intestinal cancer
Mouse models of colorectal cancer and intestinal cancer are experimental systems in which mice are genetically manipulated, fed a modified diet or challenged with chemicals to develop malignancies in the gastrointestinal tract. These models enable researchers to study the onset, progression of the disease, and understand in depth the molecular events that contribute to the development and spread of colorectal cancer. They also provide a valuable biological system, to simulate human physiological conditions, suitable for testing therapeutics that can potentially benefit patients. An important example is the development of the APC mutant mouse model of colorectal cancer and the subsequent observation that cyclooxygenase expression is an early event in colorectal carcinogenesis. Genetic disruption of the cyclooxygenase-2 (COX-2) gene or inhibition of the activity of COX-2 with chemical inhibitors reduced the polyp burden in mice. These observations gave rationale to treat human patients suffering from the familial form of the disease FAP with selective COX-2 inhibitors.
==Colorectal and intestinal cancer==


抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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